來自MassWorks用戶的聲音...
MassWorks是一個非常有效的分子式識別工具,對我們從事的天然產物未知物鑒別工作很有幫助,尤其對共流出物的化合物識別,起到關鍵的作用,彌補了NIST譜庫的不足。對低分辨的氣質以及高分辨的液質,可以大大提高化合物分子式的確認準確度。
甘肅省出入境檢驗檢疫局檢驗檢疫技術中心----周圍主任
"The ability to provide the elemental identification of unknown compounds on a routine basis by any scientist is now within one"s reach."
Eli Lilly Poster from ASMS 2007
由于MassWorks的超越性能,對任何從事質譜分析的人確定分子式已成為舉手之勞。
"Congratulations!! Once more I are am deeply impressed by sClips. In
both cases you are right with the top no. 1 [formula]!! Additionally, I find it
fantastic that you do not need a calibration standard for higher resolving mass
specs, by “just” looking at the isotope signals."
Communication from blind sample evaluation on a Leco LC-TOF Prof. Dr. Wolfgang Schwack Universit?t Hohenheim, Germany
“祝賀你們, sCLIPS再一次給我留下深深的印象。
兩次的盲樣測試,你們鑒定的分子式的選擇都是正確的結果。此外,我發(fā)現(xiàn)對高分辨質譜數(shù)據(jù),你們竟然不需要利用標準化合物進行標定,僅僅利用同位素的信號就可以做分子式的鑒定。
這簡直是太神奇了。”
這是西瓦克教授在兩次盲樣測試(Leco LC-TOF)得到正確結果后的感受。
"With PFTBA calibration performed to each GC/MS run, mass accuracy
better than 10mDa can be achieved and Spectral Accuracy of better than 99% can
be achieved to help attain reliable formula determination. The mass calibration
is stable after 11 days without significantly compromising formula
determination. While mass calibration is more susceptible to time related
variations, the Spectral Accuracy has been shown to be robust enough for formula
determination after 19 days."
Boehringer Ingelheim Pharmacueuticals Poster from ASMS 2008
MassWorks 利用PFTBA標定氣質數(shù)據(jù),質量準確度與譜圖準確度能分別達到小于10 毫道爾頓和99%., 從而可以進行可靠的分子式鑒定。PFTBA標定相當穩(wěn)定。同樣的標定在11天內產生幾乎相似的鑒定結果。質量準確度易于隨時間漂移,但譜圖準確度可保持長達19天幾乎不變,從而更適用于分子式鑒定。
"The program is very easy to learn, it literally took minutes to get
the first exciting results. On our 10 year-old triple quad, we manage to achieve
mass accuracies of 10ppm or better routinely. It has become an integral part of
our characterization pipeline for newly synthesized compounds."
Dr. Alexander Leitner University of Vienna
“使用MassWorks非常簡單,一學就會。我僅僅花了幾分鐘的時間就得到了次振奮人心的結果。我們在使用了十年有余的三重四極桿上,通常可以達到10 ppm 或者更好的質量準確度。這個軟件已成為我們鑒定合成化合物的重要組成部分。”
"Determining the elemental composition of pure materials at modest
resolution typical of quads has never been routinely practiced – CLIPS brings
that task very close to practice for the general user. It is not too much of a
stretch to suggest CLIPS will enhance the confidence of TOF-based assignments as
well, which may even challenge slower FTMS-based determinations."
User at a large midwest consumer products company
用低分辨率四極桿質譜儀可靠地確定純化合物是史無前例的–CLIPS給眾多的四極桿質譜儀操作人員。可以并不夸張地說sCLIPS會幫助由時間飛行質譜儀或傅里葉變換質譜儀進一步準確地鑒定未知化合物。
"The accurate mass profile extract ion chromatogram (AMPXIC) obtained
through accurate mass measurement and isotope profile-mode filtering [performed
with MassWorks] eliminated the false positive peaks observed using conventional
XIC in the metabolite profile."
Wyeth Research Poster from ASMS 2008
比起通常離子提取圖,準確質量輪廓離子提取圖去除了許多在代謝產物分析中的假陽性峰
恵氏公司研究人員 (ASMS2008)
"I have tested and used the MassWorks software since the summer of
2007. The main purpose for me is using its formula ID feature to confirm the
GC/MS NIST library search results for unknown chemical substance identification
especially when the [NIST] search match values are similar for more than one
compounds. The software is relatively simple to use and most times provides the
#1 match for our testing chemicals with more than 200 compounds in a variety of
chemical groups."
User from a United States Government Environmental Lab
自從2007年夏季我就測試和使用MassWorks這個軟件。我的主要目的是應用這個軟件鑒定分子式的性能去進一步核實氣質未知化合物NIST譜庫檢索的結果。尤其是當檢索結果顯示多種化合物具有相似匹配值時,MassWorks會提供另一個獨立的分子式幫助確定未知化合物。相對來說,這個軟件簡單易用。在我所測試的各種類型多于二百種化合物中,大部分由MassWorks分析結果都將正確的分子式排在位。
美國一州政府環(huán)保實驗室用戶
"Starting a little bit "speechless" from our side your Presentation
helped really changing our mindset, from "unbelieving into "believer". After
this Test with a sample taken from real life with real interferences my
colleagues and I fully agree that MassWorks is indeed a powerful tool for
advanced GC/MS analysis. We found that MassWorks is really a "must have" product
for us..."
Researcher from a large German chemical company
一開始,我們被你們的結果驚訝得啞口無言。你們的講座和演示真正地改變了我們的觀念。真是千聞不如一見。在經(jīng)過具有干擾的實際樣品的盲樣測試后,
我和我的同事都一致認為MassWorks確實是用于氣質分析十分有效的工具。我發(fā)現(xiàn)MassWorks是我們是必不可少軟件。
德國一家大型化工廠的研究人員
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